Application note

Host Cell Proteins (HCPs) identification and quantification inside AAV therapeutic drugs with HCPprofiler.

41 Amino acids analysis in serum by LC-MS/MS

Comparison between a targeted LCMS and the label free HCPprofiler solution for quantification of HCPs

pharmacokinetic study of monoclonal antibodies in rat plasma: implementation of immunoprecipitation

Intact Mass Analysis of a monoclonal Antibody

HCPprofiler Standard: Repeatability Across All Considered Matrices

HCPs detection during DSP optimization

EarlyPK for therapeutic peptide in rat serum

A targeted method for specific quantification of 74 critical Host Cell Protein

HCP analysis: ELISA or Mass Spectrometry

Downstream process comparison between production sites

Bioproduction’s transfer and uspscale evaluation on HCPs content

Comparison of HCP quantification performances using either HCP-PROFILER based calibration curves or protein standard based calibration curves

Impact of the upstream process on total amount and individual amount of HCP in the final drug products

Inter-laboratories reproducibility of protein quantification with HCP PROFILER

HCP profiler to evaluate impact of process scale up on Host Cell Protein quantity and identity

When targeted MS approach allows to detect unsuspected chemical modification during bioproduction

mAb aggregate and degradation income control using Size Exclusion Chromatography (SEC)

Quantification of 74 critical Host Cell Proteins with LC-MS and Scout MRM

Reproducibility of Host Cell Protein quantification with HCP PROFILER solution

Host Cell Protein identification and quantification in drug substance batches consequently to Down Stream Process optimisation

Bioprocess characterization based on MS-based Multi Attribute Monitoring and HCP analysis

Fast and specific method to validate cell models: application to KO models

Why mass spectrometry is also a quantitative method?

Accurate and specific quantification of targeted Host Cell Proteins

Residual protein taxonomy identification in cell & gene therapies

A multiplex identification and quantification of monoclonal antibodies

A specific identification and quantification of antigens in polyvalent vaccines

How to differentiate specific phosphorylation sites?

Early pk studies on recombinant proteins or peptides

Host Cell Proteins analysis for clinical batches comparison

Host Cell Proteins monitoring for biosimilar batch comparison

HCP monitoring for Down stream Process improvement

How LC-MS can bring specificity for biologics bioanalysis?

How to monitor your nano LC-MS system performance for proteomic analysis?